Semiquantification Study of [11C]-(R)-PK11195 PET Brain Images in Multiple Sclerosis
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چکیده
منابع مشابه
11C-(R)-PK11195 PET imaging of microglial activation and response to minocycline in zymosan-treated rats.
UNLABELLED We sought to advance methodology for studying microglial activation and putative therapeutic downregulation in response to minocycline by means of noninvasive in vivo imaging. A reproducible focal white matter lesion was used to reliably compare treatment conditions. METHODS The corpus callosum of female Sprague Dawley rats was injected with zymosan to promote microglial activation...
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Performance of two supervised cluster analysis (SVCA) algorithms for extracting reference tissue curves was evaluated to improve quantification of dynamic (R)-[(11)C]PK11195 brain positron emission tomography (PET) studies. Reference tissues were extracted from images using both a manually defined cerebellum and SVCA algorithms based on either four (SVCA4) or six (SVCA6) kinetic classes. Data f...
متن کاملMicroglial activation in perinatal rabbit brain induced by intrauterine inflammation: detection with 11C-(R)-PK11195 and small-animal PET.
UNLABELLED Intrauterine infection can lead to a fetal inflammatory response syndrome that has been implicated as one of the causes of perinatal brain injury leading to periventricular leukomalacia (PVL) and cerebral palsy. The presence of activated microglial cells has been noted in autopsy specimens of patients with PVL and in models of neonatal hypoxia and ischemia. Activated microglial cells...
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BACKGROUND Activation of glial cells is a cardinal feature in multiple sclerosis (MS) pathology, and acetate has been reported to be selectively uptaken by astrocytes in the CNS. The aim of this study was to investigate the efficacy of PET with (11)C-acetate for MS diagnosis. MATERIALS AND METHODS Six patients with relapsing-remitting MS and 6 healthy volunteers (HV) were enrolled. The (11)C-...
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BACKGROUND Positron-emission tomography and the radioligand [11C](R)-PK11195 have been used for the imaging of the translocator protein (TSPO) and applied to map microglia cells in the brain in neuropsychiatric disorders. [11C](R)-PK11195 binding has been quantified using reference region approaches, with the reference defined anatomically or using unsupervised or supervised clustering algorith...
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ژورنال
عنوان ژورنال: Revista Brasileira de Física Médica
سال: 2016
ISSN: 1984-9001,2176-8978
DOI: 10.29384/rbfm.2016.v10.n2.p39-43